Tag: Autonomic nervous system

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Autonomic Function in Insular Glioma

World Neurosurg. (2018) 118:e951-e955

Autonomic nervous system dysfunction is a known entity in strokes involving insula. It causes significant morbidity and mortality. No study to date has demonstrated autonomic nervous system dysfunction in patients with insular glioma. This is an exploratory study to identify the
subclinical autonomic dysfunctions in insular glioma.

METHODS: A total 50 patients with newly diagnosed insular glioma in the age group of 18e60 years were evaluated with heart rate variability (HRV). All the HRV parameters in patients with insular glioma were compared with normal healthy age- and sex-matched control patients.

RESULTS: There was a significant difference (P < 0.05) in most of the HRV parameters between patients and control patients. Patients with left insular glioma showed significantly increased heart rate (P [ 0.027), low-frequency normalized units (P [ 0.048), and also increased low-frequency/highfrequency ratio (P [ 0.015), which indicates sympathetic
dominance. Patients with seizures had significantly lower values of total power (P [ 0.042). No significant difference was found in terms of the extent and size of the tumor or histopathologic grades of gliomas.

CONCLUSIONS: Patients with insular gliomas have significant impairment of autonomic functions, with left insular glioma showing sympathetic dominance. Suppression of autonomic function is greater in those presenting with seizures.

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Prediction of early secondary complications in patients with spontaneous subarachnoid hemorrhage based on accelerated sympathovagal ratios

Acta Neurochir (2009) 151:1631–1637 DOI 10.1007/s00701-009-0517-9

Purpose The development of secondary complications following spontaneous subarachnoid hemorrhage (SAH) largely depends on sympathetic overexcitation. The roles of vagal activities, however, are poorly defined. Because both components of the autonomic nervous system can be explored in the frequency domain of heart rate variability (HRV), the present study aimed to determine the dynamic evolution of autonomic activities and to identify patients at high risk for complications following hemorrhage. Methods Thirty patients with SAH were enrolled in our study. Those who suffered from symptomatic vasospasm, cerebral infarction, neurogenic pulmonary edema, or early mortality within 1 week of ictus were categorized into the complication group. Spectral analysis of HRV explored three important indices of sympathetic and vagal modu- lations: low-frequency (LF), high-frequency (HF), and LF/HF ratios. Patterns of HRV dynamics within the first 3 days were compared between complication and non complication groups. The group trends, estimated by the slopes of HRV changes, were determined for further univariate and multivariate analysis. Results Our study showed that daily HRV in the complica- tion group exhibited an approximately 2.7-fold increase of sympathovagal ratio (denoted by LF/HF). This resulted from reciprocal changes of sympathoexcitation (LF) and vagal withdrawal (HF). Multivariate analysis revealed that LF/HF slope, an indicator of the trend of sympathovagal change, was an independent variable significantly associat- ed with the development of complications.

Conclusions This study confirmed that during early SAH period, patients with and without complications presented different patterns of sympathovagal changes. LF/HF slope during the first 3 days was a significant predictor of secondary complications after SAH.

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