Acta Neurochirurgica (2025) 167:255
Higher blood C-reactive protein (CRP), a marker of systemic inflammation, is significantly correlated with lower volume of the parasagittal dura (PSD). This suggests PSD volume may serve as a potential imaging marker of systemic inflammation. No significant association was found between PSD volume and subjective sleep quality.
• The study investigated the relationship between the volume of the parasagittal dura (PSD) and blood markers of systemic inflammation, mainly C-reactive protein (CRP).
• 76 patients underwent intrathecal contrast-enhanced MRI to measure PSD volume and CSF clearance, alongside blood tests for inflammatory markers.
• Higher CRP levels were significantly correlated with lower PSD volume, suggesting an association between systemic inflammation and PSD morphology.
• This inverse relationship was significant even after adjusting for confounders such as age, sex, and diagnosis.
• Other blood markers (hemoglobin, erythrocyte volume fraction) showed initial correlations with PSD volume, but these were not significant after accounting for confounders.
• Impaired sleep quality was associated with higher CRP but not with PSD volume.
• The findings suggest PSD volume may serve as a potential imaging marker of systemic inflammation, but causality remains unclear.
• Further research is needed to clarify mechanisms and clinical implications of the PSD-inflammation link.
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