J Neurosurg 142:875–883, 2025
Endoscopic third ventriculostomy (ETV) significantly improves long-term memory and visuospatial skills in patients with long-standing overt ventriculomegaly in adults (LOVA), especially those with higher premorbid IQ. The study highlights the role of cognitive reserve in facilitating cognitive recovery post-surgery.
• Endoscopic third ventriculostomy (ETV) surgery leads to cognitive improvement in patients with long-standing overt ventriculomegaly in adults (LOVA), particularly in long-term memory and visuospatial skills.
• Cognitive reserve (CR) plays a crucial role in predicting cognitive recovery post-surgery, with higher premorbid IQ linked to better outcomes.
• LOVA is a chronic form of hydrocephalus that becomes symptomatic in adulthood, often characterized by cognitive deficits and gait disturbances.
• ETV is favored over ventriculoperitoneal shunt (VPS) due to lower complication rates, making it the preferred treatment option.
• Preoperative cognitive profiles of LOVA patients show deficits primarily in long-term memory and visuospatial skills, while other cognitive domains remain unaffected.
• Postoperative improvements are significant and sustained over time, with the majority of patients reporting enhanced cognitive function and quality of life.
• Symptom duration does not hinder the efficacy of ETV, and longer symptom history may lead to better outcomes in visuospatial skills.
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