Neurosurgery 96:426–437, 2025
• Study Overview:
•Retrospective multicentric study on 39 patients with hypothalamic hamartomas (HH).
•Mean age of patients was 16 years, with a range from 6 months to 53 years.
•Ethical clearance obtained for data sharing from participating centers.
• Treatment Details:
•Gamma Knife Radiosurgery (GKRS) used with a median margin dose of 16 Gy.
•Target volume median was 0.55 cc, ranging from 0.1 to 10.00 cc.
•Majority of patients received ≥16 Gy targeting complete HH.
• Seizure Outcomes:
•55.2% achieved good seizure control (Engel I/II).
•44.8% were in Engel III/IV status.
•No significant difference in seizure outcomes based on prescribed dose.
• Complications and Side Effects:
•Two patients developed new onset hormonal deficiency.
•No new onset visual deterioration observed.
•Eight patients experienced a transient increase in seizures.
• Endocrinological Impact:
•17.9% of patients presented with both precocious puberty (PP) and epilepsy.
•No significant change in endocrinological profile post-radiosurgery.
• Follow-up and Long-term Effects:
•Median follow-up duration was 5 years.
•Regression in hamartoma volume observed in 28% of patients.
•Long-term follow-up essential for observing significant outcomes
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