J Neurosurg 142:637–646, 2025
• Study Overview: TOBAS study on conservative management of brain AVMs.
• Objective: Monitor outcomes of patients with brain AVMs managed conservatively.
• Primary Outcome: Death or dependency (mRS score > 2) at 10 years.
• Patient Recruitment: 1010 patients recruited, 498 in observation registry.
• Follow-up Results: Low incidence of death or disability, 1.7% per year.
• Risk Factors: History of rupture, infratentorial location, age ≥ 55 years increase poor outcomes.
• SAEs Incidence: 3.6 per 100 patient-years, higher in ruptured AVMs.
• Methodology: Kaplan-Meier curves, Cox log-rank tests used for analysis.
• Study Design: Multicenter, includes randomized trials and prospective registries.
• Data Collection: Simple electronic forms, Good Clinical Practice compliance.
• Patient Characteristics: Majority with unruptured, low-grade AVMs.
• Statistical Analysis: Cox models and hazard ratios used.
• Conclusions: Observed patients had low rates of adverse neurological events
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