• Objective: The study investigates the lateral compartment of the cavernous sinus (CS) and its surgical relevance in adenoma surgery using the endoscopic endonasal approach.
• Methods: Dissection was performed on 22 colored silicone-injected specimens to identify anatomical landmarks and techniques for mobilizing the internal carotid artery (ICA).
• Findings: The lateral compartment is divided into two subcompartments, with the upper housing the lateral parasellar ligament (LPL) and inferolateral trunk (ILT), and the lower containing sympathetic nerve branches.
• LPL and ILT: The LPL was identified in 86% of hemispheres, with varying configurations, and the ILT was found in 93%, primarily originating from the horizontal ICA segment.
• Techniques: Transection of the LPL, ILT, and COM facilitates medial ICA mobilization, enhancing access to the lateral compartment.
• Conclusions: The study underscores the anatomical intricacies of the lateral compartment and the potential benefits of the lateral transcavernous approach.
• Limitations: The study’s findings are based on cadaveric dissections, which may not fully replicate live surgical conditions.
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