J Neurosurg 142:1271–1279, 2025
A meta-analysis of unilateral MR-guided focused ultrasound thalamotomy for pharmacoresistant tremors shows no significant cognitive or emotional decline post-procedure. However, the limited studies and short-term assessments necessitate further research, especially on long-term effects and bilateral procedures.
• Objective: Evaluate cognitive and emotional effects of unilateral MR-guided focused ultrasound (MRgFUS) thalamotomy in patients with pharmacoresistant tremors.
• Methods: Conducted a meta-analysis following PRISMA guidelines, focusing on cognitive functions pre- and post-procedure.
• Results: No significant deterioration in cognitive domains or emotional states post-procedure.
• Sample: Included 112 patients, mostly with essential tremor and some with Parkinson’s disease.
• Findings: MRgFUS thalamotomy is safe concerning cognitive and emotional outcomes, but more research is needed for long-term effects.
• Limitations: Small number of studies, short-term assessments, and potential publication bias.
• Conclusion: Encouraging findings on safety, but further comprehensive investigations are necessary.
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