Operative Neurosurgery 29:238–246, 2025
This study retrospectively analyzes cerebellar cavernous malformations (cCMs), presenting a tailored microsurgical treatment algorithm. Nearly half of cCM patients required surgery, with individualized approaches improving outcomes. The study highlights the rarity, management challenges, and need for further research into optimal surgical strategies for cCMs.
• Cerebellar cavernous malformations (cCMs) are rare vascular brain lesions, representing 6.5% of all CMs in a large cohort.
• Almost half (49%) of cCM patients underwent surgical treatment, with approaches tailored to lesion location using a specific algorithm.
• Surgical strategies included supracerebellar-infratentorial, telovelar, suboccipital transcortical, and retrosigmoid approaches.
• Surgically treated patients showed significant improvement in functional outcomes, with no mortality and a 27.5% morbidity rate.
• No significant risk factors for postoperative morbidity were identified, including lesion location or associated developmental venous anomalies.
• Conservative management was chosen for asymptomatic or mildly symptomatic patients; about half of cCM patients were managed this way.
• The study provides an individualized surgical algorithm and highlights the need for further research and minimally invasive techniques.
• Main limitations include retrospective single-center design, small surgical sample size, and lack of pediatric or radiation therapy cases.

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