Acta Neurochir (2015) 157:2143–2147
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using an MRI-guided and MRI-verified technique without microelectrode recording is an effective and safe surgical treatment for patients with Parkinson’s disease (PD).
Objectives To assess the anatomical accuracy of lead placement after MRI-guided, MRI-verified STN DBS using postmortem histology and high-field MRI at 9.4 T.
Methods We conducted post-mortem analysis of a patient’s brain who had had MRI-guided, MRI-verified STN DBS for PD, using 9.4-TMRI and histology. After death, the brain was retrieved and a block including the electrode tracks down to the mesencephalon was examined with high-field MRI at 9.4 T and histological analysis.
Results High-field MRI images and corresponding histological examination showed that each electrode track ended within the intended target area, and that DBS did not cause significant neuroparenchymal tissue damage.
Conclusions This study supports the anatomical accuracy of the MRI-guided and MRI-verified method of STN DBS.
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