Neurosurgery 96:328–337, 2025
• Study Focus: Genomic alterations in oligodendrogliomas using standardized NGS panels.
• Key Genes: CIC, FUBP1, and TERTp are the most frequently altered genes.
• Patient Cohort: Retrospective analysis of 95 patients with NGS reports.
• Methodology: Kaplan-Meier plots and log-rank tests for survival analysis.
• Findings: CIC alterations linked to reduced PFS at earlier time points.
• Additional Genes: NOTCH1 and PIK3CA show potential prognostic value.
• Clinical Implications: Potential integration of genomic alterations into clinical practice.
• Future Research: Larger studies needed to validate findings.
• Seizures: Most common presenting symptom in patients.
• Treatment: Majority underwent surgery followed by observation.
• Tumor Grade: Predominantly WHO grade 2 at first surgery.
• Mutation Analysis: 435 cancer-related genes analyzed.
• Statistical Tools: MATLAB R2022b used for analysis.
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