J Neurosurg 142:884–891, 2025
• Study Objective: Quantify morphological changes in trigeminal nerve causing trigeminal neuralgia (TN).
• Methods: Retrospective analysis of patients with TN undergoing microvascular decompression (MVD).
• Parameters Analyzed: Centerline length, curvature, torsion, cross-sectional area, flattening ratio, long-axis angle.
• Results: Affected side showed longer centerline, greater curvature, smaller area pre-surgery.
• Postoperative Changes: Affected side showed shorter centerline, larger cross-sectional area post-surgery.
• Concordance Rate: 91.4% between intraoperative findings and 3D model flexion locations.
• Accuracy of Segmentation: Manual segmentation showed 80%-90% concordance with surgical findings.
• Limitations: Retrospective, single institution, manual segmentation, not fully matching surgical findings.
• Further Analyses: Needed for patients without neurovascular compression (NVC) and with venous compression.
• Study Implications: Method helps analyze TN pathophysiology, aid diagnosis, predict treatment efficacy.
• Statistical Analysis: Mann-Whitney U-test, significance set at p < 0.05
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